Methylation and Transcripts Expression at the Imprinted GNAS Locus in Human Embryonic and Induced Pluripotent Stem Cells and Their Derivatives

Data from the literature indicate that genomic imprint marks are disturbed in human pluripotent stem cells (PSCs). GNAS is an imprinted locus that produces one biallelic (Gsα) and four monoallelic (NESP55, GNAS-AS1, XLsα, and A/B) transcripts due to differential methylation of their promoters (DMR)....

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Publicado no:Stem Cell Reports
Main Authors: Grybek, Virginie, Aubry, Laetitia, Maupetit-Méhouas, Stéphanie, Le Stunff, Catherine, Denis, Cécile, Girard, Mathilde, Linglart, Agnès, Silve, Caroline
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4266011/
https://ncbi.nlm.nih.gov/pubmed/25241742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2014.07.002
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