Transcriptional Repression by the BRG1-SWI/SNF Complex Affects the Pluripotency of Human Embryonic Stem Cells

The SWI/SNF complex plays an important role in mouse embryonic stem cells (mESCs), but it remains to be determined whether this complex is required for the pluripotency of human ESCs (hESCs). Using RNAi, we demonstrated that depletion of BRG1, the catalytic subunit of the SWI/SNF complex, led to imp...

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Veröffentlicht in:Stem Cell Reports
Hauptverfasser: Zhang, Xiaoli, Li, Bing, Li, Wenguo, Ma, Lijuan, Zheng, Dongyan, Li, Leping, Yang, Weijing, Chu, Min, Chen, Wei, Mailman, Richard B., Zhu, Jun, Fan, Guoping, Archer, Trevor K., Wang, Yuan
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4266000/
https://ncbi.nlm.nih.gov/pubmed/25241744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2014.07.004
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