Proteasome dysfunction induces muscle growth defects and protein aggregation

The ubiquitin–proteasome and autophagy–lysosome pathways are the two major routes of protein and organelle clearance. The role of the proteasome pathway in mammalian muscle has not been examined in vivo. In this study, we report that the muscle-specific deletion of a crucial proteasomal gene, Rpt3 (...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Cell Sci
Main Authors: Kitajima, Yasuo, Tashiro, Yoshitaka, Suzuki, Naoki, Warita, Hitoshi, Kato, Masaaki, Tateyama, Maki, Ando, Risa, Izumi, Rumiko, Yamazaki, Maya, Abe, Manabu, Sakimura, Kenji, Ito, Hidefumi, Urushitani, Makoto, Nagatomi, Ryoichi, Takahashi, Ryosuke, Aoki, Masashi
Format: Artigo
Jezik:Inglês
Izdano: The Company of Biologists 2014
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4265737/
https://ncbi.nlm.nih.gov/pubmed/25380823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.150961
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