Proteasome dysfunction induces muscle growth defects and protein aggregation

The ubiquitin–proteasome and autophagy–lysosome pathways are the two major routes of protein and organelle clearance. The role of the proteasome pathway in mammalian muscle has not been examined in vivo. In this study, we report that the muscle-specific deletion of a crucial proteasomal gene, Rpt3 (...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Cell Sci
Prif Awduron: Kitajima, Yasuo, Tashiro, Yoshitaka, Suzuki, Naoki, Warita, Hitoshi, Kato, Masaaki, Tateyama, Maki, Ando, Risa, Izumi, Rumiko, Yamazaki, Maya, Abe, Manabu, Sakimura, Kenji, Ito, Hidefumi, Urushitani, Makoto, Nagatomi, Ryoichi, Takahashi, Ryosuke, Aoki, Masashi
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The Company of Biologists 2014
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4265737/
https://ncbi.nlm.nih.gov/pubmed/25380823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.150961
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