Proteasome dysfunction induces muscle growth defects and protein aggregation

The ubiquitin–proteasome and autophagy–lysosome pathways are the two major routes of protein and organelle clearance. The role of the proteasome pathway in mammalian muscle has not been examined in vivo. In this study, we report that the muscle-specific deletion of a crucial proteasomal gene, Rpt3 (...

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Veröffentlicht in:J Cell Sci
Hauptverfasser: Kitajima, Yasuo, Tashiro, Yoshitaka, Suzuki, Naoki, Warita, Hitoshi, Kato, Masaaki, Tateyama, Maki, Ando, Risa, Izumi, Rumiko, Yamazaki, Maya, Abe, Manabu, Sakimura, Kenji, Ito, Hidefumi, Urushitani, Makoto, Nagatomi, Ryoichi, Takahashi, Ryosuke, Aoki, Masashi
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Company of Biologists 2014
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4265737/
https://ncbi.nlm.nih.gov/pubmed/25380823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.150961
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