Growth and metastasis of B16-F10 melanoma cells is not critically dependent on host CD73 expression in mice

BACKGROUND: Recent studies have suggested that adenosine generated by ecto-5′-nucleotidase (CD73) in the tumor microenvironment plays a major role in promoting tumor growth by suppressing the immune response and stimulating angiogenesis via A2A and A2B receptors. However, adenosine has also been rep...

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Vydáno v:BMC Cancer
Hlavní autoři: Burghoff, Sandra, Gong, Xuan, Viethen, Claudia, Jacoby, Christoph, Flögel, Ulrich, Bongardt, Sabine, Schorr, Anne, Hippe, Andreas, Homey, Bernhard, Schrader, Jürgen
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2014
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4265456/
https://ncbi.nlm.nih.gov/pubmed/25465225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-14-898
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