Pseudogene PTENP1 Functions as a Competing Endogenous RNA to Suppress Clear-Cell Renal Cell Carcinoma Progression

PTENP1 is a pseudogene of the PTEN tumor suppression gene (TSG). The functions of PTENP1 in clear-cell renal cell carcinoma (ccRCC) have not yet been studied. We found that PTENP1 is downregulated in ccRCC tissues and cells due to methylation. PTENP1 and PTEN are direct targets of miRNA miR21 and th...

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Detalhes bibliográficos
Publicado no:Mol Cancer Ther
Main Authors: Yu, Gan, Yao, Weimin, Gumireddy, Kiranmai, Li, Anping, Wang, Ji, Xiao, Wei, Chen, Ke, Xiao, Haibing, Li, Heng, Tang, Kun, Ye, Zhangqun, Huang, Qihong, Xu, Hua
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4265235/
https://ncbi.nlm.nih.gov/pubmed/25249556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-14-0245
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