Synthesis and antiviral activity of 7-deazaneplanocin A against orthopoxviruses (vaccinia and cowpox virus)

An efficient method for the synthesis of 7-deazaneplanocin A (2) has been accomplished by the condensation of cyclopentenol 3 with 6-chloro-7-deazapurine followed by subsequent functional group manipulations. The synthesized 7-deazaneplanocin A (2) exhibited potent antiviral activity against cowpox...

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Bibliographic Details
Published in:Bioorg Med Chem Lett
Main Authors: Arumugham, Balakumar, Kim, Hyo-Joong, Prichard, Mark N., Kern, Earl R., Chu, Chung K.
Format: Artigo
Language:Inglês
Published: 2005
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4264103/
https://ncbi.nlm.nih.gov/pubmed/16275078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2005.10.007
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