TNF-mediated inflammation represses GATA1 and activates p38 MAP kinase in RPS19-deficient hematopoietic progenitors

Diamond-Blackfan anemia (DBA) is an inherited disorder characterized by defects in erythropoiesis, congenital abnormalities, and predisposition to cancer. Approximately 25% of DBA patients have a mutation in RPS19, which encodes a component of the 40S ribosomal subunit. Upregulation of p53 contribut...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Bibikova, Elena, Youn, Min-Young, Danilova, Nadia, Ono-Uruga, Yukako, Konto-Ghiorghi, Yoan, Ochoa, Rachel, Narla, Anupama, Glader, Bertil, Lin, Shuo, Sakamoto, Kathleen M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2014
Assuntos:
Red Cells, Iron, and Erythropoiesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4263986/
https://ncbi.nlm.nih.gov/pubmed/25270909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-06-584656
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