Exosomal miR-135b shed from hypoxic multiple myeloma cells enhances angiogenesis by targeting factor-inhibiting HIF-1

Exosomes are small endosome-derived vesicles containing a wide range of functional proteins, mRNA, and miRNA. Exosomal miRNA from cancer cells helps modulate the microenvironment. In multiple myeloma (MM), the massive proliferation of malignant plasma cells causes hypoxia. To date, the majority of i...

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Bibliografiska uppgifter
I publikationen:Blood
Huvudupphovsmän: Umezu, Tomohiro, Tadokoro, Hiroko, Azuma, Kenko, Yoshizawa, Seiichiro, Ohyashiki, Kazuma, Ohyashiki, Junko H.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society of Hematology 2014
Ämnen:
Lymphoid Neoplasia
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4263983/
https://ncbi.nlm.nih.gov/pubmed/25320245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-05-576116
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