Lipidomics and genomics of Mycobacterium tuberculosis reveal lineage-specific trends in mycolic acid biosynthesis

Mycolic acids (MAs) are α-alkyl, β-hydroxy long-chain fatty acids found in abundance in the cell envelope of the Mycobacterium tuberculosis complex (MTBC). MAs form an efficient permeability barrier, modulate host innate immune responses, and are the targets of several anti-tuberculosis drugs. Using...

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Detalhes bibliográficos
Publicado no:Microbiologyopen
Main Authors: Portevin, Damien, Sukumar, Sudarkodi, Coscolla, Mireia, Shui, Guanghou, Li, Bowen, Guan, Xue Li, Bendt, Anne K, Young, Douglas, Gagneux, Sebastien, Wenk, Markus R
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2014
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4263507/
https://ncbi.nlm.nih.gov/pubmed/25238051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mbo3.193
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