Neuromuscular synapse integrity requires linkage of acetylcholine receptors to postsynaptic intermediate filament networks via rapsyn–plectin 1f complexes

Mutations in the cytolinker protein plectin lead to grossly distorted morphology of neuromuscular junctions (NMJs) in patients suffering from epidermolysis bullosa simplex (EBS)-muscular dystrophy (MS) with myasthenic syndrome (MyS). Here we investigated whether plectin contributes to the structural...

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Publié dans:Mol Biol Cell
Auteurs principaux: Mihailovska, Eva, Raith, Marianne, Valencia, Rocio G., Fischer, Irmgard, Banchaabouchi, Mumna Al, Herbst, Ruth, Wiche, Gerhard
Format: Artigo
Langue:Inglês
Publié: The American Society for Cell Biology 2014
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4263455/
https://ncbi.nlm.nih.gov/pubmed/25318670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E14-06-1174
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