Maf1 Is a Novel Target of PTEN and PI3K Signaling That Negatively Regulates Oncogenesis and Lipid Metabolism

Maf1 was initially identified as a transcriptional repressor of RNA pol III-transcribed genes, yet little is known about its other potential target genes or its biological function. Here, we show that Maf1 is a key downstream target of PTEN that drives both its tumor suppressor and metabolic functio...

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Опубликовано в: :PLoS Genet
Главные авторы: Palian, Beth M., Rohira, Aarti D., Johnson, Sandra A. S., He, Lina, Zheng, Ni, Dubeau, Louis, Stiles, Bangyan L., Johnson, Deborah L.
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2014
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4263377/
https://ncbi.nlm.nih.gov/pubmed/25502566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004789
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