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Activation mechanism of AMPA receptors illuminated by complexes with cone snail toxin, allosteric potentiator and orthosteric agonists

AMPA-sensitive glutamate receptors are crucial to the structural and dynamical properties of the brain, to the development and function of the central nervous system and to the treatment of neurological conditions from depression to cognitive impairment. However, the molecular principles underlying...

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Detalhes bibliográficos
Publicado no:Science
Main Authors: Chen, Lei, Dürr, Katharina L., Gouaux, Eric
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4263349/
https://ncbi.nlm.nih.gov/pubmed/25103405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1258409
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