Abuse potential, pharmacokinetics, pharmacodynamics, and safety of intranasally administered crushed oxycodone HCl abuse-deterrent controlled-release tablets in recreational opioid users

The objective of this study was to evaluate abuse potential, pharmacokinetics, pharmacodynamics, and safety of intranasally administered, crushed reformulated OxyContin® (oxycodone HCl controlled-release) tablets (ORF), relative to crushed original OxyContin® (OC), oxycodone powder (Oxy API), and OC...

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Vydáno v:J Clin Pharmacol
Hlavní autoři: Harris, Stephen C, Perrino, Peter J, Smith, Ira, Shram, Megan J, Colucci, Salvatore V, Bartlett, Cynthia, Sellers, Edward M
Médium: Artigo
Jazyk:Inglês
Vydáno: BlackWell Publishing Ltd 2014
Témata:
Drug Abuse Deterrence
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4263153/
https://ncbi.nlm.nih.gov/pubmed/24243216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcph.235
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