2’,3’-cAMP, 3’-AMP, 2’-AMP and Adenosine Inhibit TNF-α and CXCL10 Production From Activated Primary Murine Microglia via A(2A) Receptors

BACKGROUND: Some cells, tissues and organs release 2’,3’-cAMP (a positional isomer of 3’,5’-cAMP) and convert extracellular 2’,3’-cAMP to 2’-AMP plus 3’-AMP and convert these AMPs to adenosine (called the extracellular 2’,3’-cAMP-adenosine pathway). Recent studies show that microglia have an extrace...

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Bibliographic Details
Published in:Brain Res
Main Authors: Newell, Elizabeth A., Exo, Jennifer L., Verrier, Jonathan D., Jackson, Travis C., Gillespie, Delbert G., Janesko-Feldman, Keri, Kochanek, Patrick M., Jackson, Edwin K.
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4262711/
https://ncbi.nlm.nih.gov/pubmed/25451117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.brainres.2014.10.059
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