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A modular switch for spatial Ca(2+) selectivity in the calmodulin regulation of CaV channels
Ca(2+)/calmodulin-dependent regulation of voltage-gated Ca(V)1-2 Ca(2+) channels exhibits extraordinary modes of spatial Ca(2+) decoding and channel modulation(1–6), vital for many biological functions(6–9). A single calmodulin (CaM) constitutively associates with the channel carboxy tail(3,10–13),...
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| Veröffentlicht in: | Nature |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2008
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4262256/ https://ncbi.nlm.nih.gov/pubmed/18235447 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature06529 |
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