Induction of multiple drug resistance in HMEC-1 endothelial cells after long-term exposure to sunitinib

Multiple drug resistance is still an unsolved problem in cancer therapy. Our previous study demonstrated that the chemotherapeutic drug doxorubicin (Dox) induced upregulation of P-glycoprotein (P-gp) in endothelial cells, resulting in a 20-fold increase in drug resistance and reduced efficiency of D...

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Detalhes bibliográficos
Publicado no:Onco Targets Ther
Main Authors: Huang, Limin, Hu, Chaoquan, Di Benedetto, Mélanie, Varin, Rémi, Liu, Jielin, Wang, Li, Vannier, Jean-Pierre, Jin, Jian, Janin, Anne, Lu, He, Li, Hong
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2014
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4262216/
https://ncbi.nlm.nih.gov/pubmed/25587220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/OTT.S67251
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