Neutrophils with myeloid derived suppressor function deplete arginine and constrain T cell function in septic shock patients

INTRODUCTION: Impaired T cell function in sepsis is associated with poor outcome, but the mechanisms are unclear. In cancer, arginase-expressing myeloid derived suppressor cells (MDSCs) deplete arginine, impair T cell receptor CD3 zeta-chain expression and T cell function and are linked to poor clin...

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Detalhes bibliográficos
Publicado no:Crit Care
Main Authors: Darcy, Christabelle J, Minigo, Gabriela, Piera, Kim A, Davis, Joshua S, McNeil, Yvette R, Chen, Youwei, Volkheimer, Alicia D, Weinberg, J Brice, Anstey, Nicholas M, Woodberry, Tonia
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4261583/
https://ncbi.nlm.nih.gov/pubmed/25084831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/cc14003
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