The dUTPase-related gene of bovine immunodeficiency virus is critical for viral replication, despite the lack of dUTPase activity of the encoded protein

BACKGROUND: Deoxyuridine 5′-triphosphate nucleotide-hydrolases (dUTPases) are essential for maintaining low intra-cellular dUTP/dTTP ratios. Therefore, many viruses encode this enzyme to prevent dUTP incorporation into their genomes instead of dTTP. Among the lentiviruses, the non-primate viruses ex...

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Bibliografiske detaljer
Udgivet i:Retrovirology
Main Authors: Voronin, Nickolay, Herzig, Eytan, Hizi, Amnon
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2014
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4261571/
https://ncbi.nlm.nih.gov/pubmed/25117862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-11-60
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