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Hypochlorous acid via peroxynitrite activates protein kinase Cθ and insulin resistance in adipocytes
We recently reported that genetic deletion of myeloperoxidase (MPO) alleviates obesity-related insulin resistance in mice in vivo. How MPO impairs insulin sensitivity in adipocytes is poorly characterized. As hypochlorous acid (HOCl) is a principal oxidant product generated by MPO, we evaluated the...
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| Pubblicato in: | J Mol Endocrinol |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Bioscientifica Ltd
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4261204/ https://ncbi.nlm.nih.gov/pubmed/25381390 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1530/JME-14-0213 |
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