Blockade of mGluR5 in the nucleus accumbens shell but not core attenuates heroin seeking behavior in rats

AIM: Glutamatergic neurotransmission in the nucleus accumbens (NAc) is crucial for the relapse to heroin seeking. The aim of this study was to determine whether mGluR5 in the NAc core or shell involved in heroin seeking behavior in rats. METHODS: Male SD rats were self-administered heroin under a fi...

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Bibliografiske detaljer
Udgivet i:Acta Pharmacol Sin
Main Authors: Lou, Zhong-ze, Chen, Ling-hong, Liu, Hui-feng, Ruan, Lie-min, Zhou, Wen-hua
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2014
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4261128/
https://ncbi.nlm.nih.gov/pubmed/25399651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2014.93
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