Blockade of mGluR5 in the nucleus accumbens shell but not core attenuates heroin seeking behavior in rats

AIM: Glutamatergic neurotransmission in the nucleus accumbens (NAc) is crucial for the relapse to heroin seeking. The aim of this study was to determine whether mGluR5 in the NAc core or shell involved in heroin seeking behavior in rats. METHODS: Male SD rats were self-administered heroin under a fi...

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Detalhes bibliográficos
Publicado no:Acta Pharmacol Sin
Main Authors: Lou, Zhong-ze, Chen, Ling-hong, Liu, Hui-feng, Ruan, Lie-min, Zhou, Wen-hua
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4261128/
https://ncbi.nlm.nih.gov/pubmed/25399651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2014.93
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