Roles of P-glycoprotein and multidrug resistance protein in transporting para-aminosalicylic acid and its N-acetylated metabolite in mice brain

AIM: Para-aminosalicylic acid (PAS) is effective in the treatment of manganism-induced neurotoxicity (manganism). In this study we investigated the roles of P-glycoprotein (MDR1a) and multidrug resistance protein (MRP) in transporting PAS and its N-acetylated metabolite AcPAS through blood-brain bar...

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Detalhes bibliográficos
Publicado no:Acta Pharmacol Sin
Main Authors: Hong, Lan, Xu, Cong, O'Neal, Stefanie, Bi, Hui-chang, Huang, Min, Zheng, Wei, Zeng, Su
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4261121/
https://ncbi.nlm.nih.gov/pubmed/25418377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2014.103
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