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Transcription factor Sp4 regulates expression of Nervous Wreck 2 to control NMDAR1 levels and dendrite patterning

Glutamatergic signaling through N-methyl-D-aspartate receptors (NMDARs) is important for neuronal development and plasticity and is often dysregulated in psychiatric disorders. Mice mutant for the transcription factor Sp4 have reduced levels of NMDAR subunit 1 (NR1) protein, but not mRNA, and exhibi...

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Detalhes bibliográficos
Publicado no:Dev Neurobiol
Main Authors: Sun, Xinxin, Pinacho, Raquel, Saia, Gregory, Punko, Diana, Meana, J.Javier, Ramos, Belén, Gill, Grace
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4261064/
https://ncbi.nlm.nih.gov/pubmed/25045015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/dneu.22212
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