PRKACA Mediates Resistance to HER2-Targeted Therapy in Breast Cancer Cells and Restores Anti-Apoptotic Signaling

Targeting HER2 with antibodies or small molecule inhibitors in HER2-positive breast cancer leads to improved survival, but resistance is a common clinical problem. To uncover novel mechanisms of resistance to anti-HER2 therapy in breast cancer, we performed a kinase open reading frame (ORF) screen t...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Moody, Susan E., Schinzel, Anna C., Singh, Shambhavi, Izzo, Francesca, Strickland, Matthew R., Luo, Leo, Thomas, Sapana R., Boehm, Jesse S., Kim, So Young, Wang, Zhigang C., Hahn, William C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4261061/
https://ncbi.nlm.nih.gov/pubmed/24909179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2014.153
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