Metabolic Signatures of Adiposity in Young Adults: Mendelian Randomization Analysis and Effects of Weight Change

BACKGROUND: Increased adiposity is linked with higher risk for cardiometabolic diseases. We aimed to determine to what extent elevated body mass index (BMI) within the normal weight range has causal effects on the detailed systemic metabolite profile in early adulthood. METHODS AND FINDINGS: We used...

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Vydáno v:PLoS Med
Hlavní autoři: Würtz, Peter, Wang, Qin, Kangas, Antti J., Richmond, Rebecca C., Skarp, Joni, Tiainen, Mika, Tynkkynen, Tuulia, Soininen, Pasi, Havulinna, Aki S., Kaakinen, Marika, Viikari, Jorma S., Savolainen, Markku J., Kähönen, Mika, Lehtimäki, Terho, Männistö, Satu, Blankenberg, Stefan, Zeller, Tanja, Laitinen, Jaana, Pouta, Anneli, Mäntyselkä, Pekka, Vanhala, Mauno, Elliott, Paul, Pietiläinen, Kirsi H., Ripatti, Samuli, Salomaa, Veikko, Raitakari, Olli T., Järvelin, Marjo-Riitta, Smith, George Davey, Ala-Korpela, Mika
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2014
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4260795/
https://ncbi.nlm.nih.gov/pubmed/25490400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pmed.1001765
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