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A Twist on Facial Selectivity of Hydride Reductions of Cyclic Ketones: Twist-Boat Conformers in Cyclohexanone, Piperidone, and Tropinone Reactions

[Image: see text] The role of twist-boat conformers of cyclohexanones in hydride reductions was explored. The hydride reductions of a cis-2,6-disubstituted N-acylpiperidone, an N-acyltropinone, and tert-butylcyclohexanone by lithium aluminum hydride and by a bulky borohydride reagent were investigat...

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Библиографические подробности
Опубликовано в: :J Org Chem
Главные авторы: Neufeldt, Sharon R., Jiménez-Osés, Gonzalo, Comins, Daniel L., Houk, K. N.
Формат: Artigo
Язык:Inglês
Опубликовано: American Chemical Society 2014
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4260662/
https://ncbi.nlm.nih.gov/pubmed/25372509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo5022635
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