Structure of the meningococcal vaccine antigen NadA and epitope mapping of a bactericidal antibody

Serogroup B Neisseria meningitidis (MenB) is a major cause of severe sepsis and invasive meningococcal disease, which is associated with 5–15% mortality and devastating long-term sequelae. Neisserial adhesin A (NadA), a trimeric autotransporter adhesin (TAA) that acts in adhesion to and invasion of...

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Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Malito, Enrico, Biancucci, Marco, Faleri, Agnese, Ferlenghi, Ilaria, Scarselli, Maria, Maruggi, Giulietta, Lo Surdo, Paola, Veggi, Daniele, Liguori, Alessia, Santini, Laura, Bertoldi, Isabella, Petracca, Roberto, Marchi, Sara, Romagnoli, Giacomo, Cartocci, Elena, Vercellino, Irene, Savino, Silvana, Spraggon, Glen, Norais, Nathalie, Pizza, Mariagrazia, Rappuoli, Rino, Masignani, Vega, Bottomley, Matthew James
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2014
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4260552/
https://ncbi.nlm.nih.gov/pubmed/25404323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1419686111
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