Platelets release mitochondria serving as substrate for bactericidal group IIA-secreted phospholipase A(2) to promote inflammation

Mitochondrial DNA (mtDNA) is a highly potent inflammatory trigger and is reportedly found outside the cells in blood in various pathologies. Platelets are abundant in blood where they promote hemostasis. Although lacking a nucleus, platelets contain functional mitochondria. On activation, platelets...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Boudreau, Luc H., Duchez, Anne-Claire, Cloutier, Nathalie, Soulet, Denis, Martin, Nicolas, Bollinger, James, Paré, Alexandre, Rousseau, Matthieu, Naika, Gajendra S., Lévesque, Tania, Laflamme, Cynthia, Marcoux, Geneviève, Lambeau, Gérard, Farndale, Richard W., Pouliot, Marc, Hamzeh-Cognasse, Hind, Cognasse, Fabrice, Garraud, Olivier, Nigrovic, Peter A., Guderley, Helga, Lacroix, Steve, Thibault, Louis, Semple, John W., Gelb, Michael H., Boilard, Eric
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2014
Assuntos:
Plenary Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4260364/
https://ncbi.nlm.nih.gov/pubmed/25082876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-05-573543
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