STAT5 programs a distinct subset of GM-CSF-producing T helper cells that is essential for autoimmune neuroinflammation

T helper (T(H))-cell subsets, such as T(H)1 and T(H)17, mediate inflammation in both peripheral tissues and central nervous system. Here we show that STAT5 is required for T helper-cell pathogenicity in autoimmune neuroinflammation but not in experimental colitis. Although STAT5 promotes regulatory...

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Detalhes bibliográficos
Publicado no:Cell Res
Main Authors: Sheng, Wanqiang, Yang, Fan, Zhou, Yi, Yang, Henry, Low, Pey Yng, Kemeny, David Michael, Tan, Patrick, Moh, Akira, Kaplan, Mark H, Zhang, Yongliang, Fu, Xin-Yuan
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4260352/
https://ncbi.nlm.nih.gov/pubmed/25412660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2014.154
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