Hindrance of binding to class II major histocompatibility complex molecules by a single amino acid residue contiguous to a determinant leads to crypticity of the determinant as well as lack of response to the protein antigen.
The immune system has evolved the potential to respond to a wide variety of antigens, yet unresponsiveness to many foreign determinants is encountered frequently. Here, we report a lack of response to a particular determinant, hen egg lysozyme (HEL)-(46-61)-peptide (p46-61), in C57BL/6 (H-2b) mice,...
I tiakina i:
| I whakaputaina i: | Proc Natl Acad Sci U S A |
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| Ngā kaituhi matua: | , , |
| Hōputu: | Artigo |
| Reo: | Inglês |
| I whakaputaina: |
National Academy of Sciences
1995
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| Ngā marau: | |
| Urunga tuihono: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC42603/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7533299/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.5.1779 |
| Ngā Tūtohu: |
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