Molecular and Cellular Characterization of a Zebrafish Optic Pathway Tumor Line Implicates Glia-Derived Progenitors in Tumorigenesis

In this study we describe the molecular and cellular characterization of a zebrafish mutant that develops tumors in the optic pathway. Heterozygous Tg(flk1:RFP)is18 transgenic adults develop tumors of the retina, optic nerve and optic tract. Molecular and genetic mapping demonstrate the tumor phenot...

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Pubblicato in:PLoS One
Autori principali: Solin, Staci L., Wang, Ying, Mauldin, Joshua, Schultz, Laura E., Lincow, Deborah E., Brodskiy, Pavel A., Jones, Crystal A., Syrkin-Nikolau, Judith, Linn, Jasmine M., Essner, Jeffrey J., Hostetter, Jesse M., Whitley, Elizabeth M., Cameron, J. Douglas, Chou, Hui-Hsien, Severin, Andrew J., Sakaguchi, Donald S., McGrail, Maura
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2014
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4259487/
https://ncbi.nlm.nih.gov/pubmed/25485542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0114888
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