Molecular and Cellular Characterization of a Zebrafish Optic Pathway Tumor Line Implicates Glia-Derived Progenitors in Tumorigenesis

In this study we describe the molecular and cellular characterization of a zebrafish mutant that develops tumors in the optic pathway. Heterozygous Tg(flk1:RFP)is18 transgenic adults develop tumors of the retina, optic nerve and optic tract. Molecular and genetic mapping demonstrate the tumor phenot...

Full description

Saved in:
Bibliographic Details
Published in:PLoS One
Main Authors: Solin, Staci L., Wang, Ying, Mauldin, Joshua, Schultz, Laura E., Lincow, Deborah E., Brodskiy, Pavel A., Jones, Crystal A., Syrkin-Nikolau, Judith, Linn, Jasmine M., Essner, Jeffrey J., Hostetter, Jesse M., Whitley, Elizabeth M., Cameron, J. Douglas, Chou, Hui-Hsien, Severin, Andrew J., Sakaguchi, Donald S., McGrail, Maura
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4259487/
https://ncbi.nlm.nih.gov/pubmed/25485542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0114888
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items