Amelioration of Hypercholesterolemia by an EGFR Tyrosine Kinase Inhibitor in Mice with Liver-Specific Knockout of Mig-6

Mitogen-inducible gene 6 (Mig-6) is a negative feedback inhibitor of epidermal growth factor receptor (EGFR) signaling. We previously found that Mig-6 plays a critical role in the regulation of cholesterol homeostasis and in bile acid synthesis. In this study, we investigated the effects of EGFR inh...

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Bibliographic Details
Published in:PLoS One
Main Authors: Lee, Jun Choul, Park, Byung Kil, Choung, Sorim, Kim, Ji Min, Joung, Kyong Hye, Lee, Ju Hee, Kim, Koon Soon, Kim, Hyun Jin, Jeong, Jae-Wook, Rhee, Sang Dal, Ku, Bon Jeong
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4259477/
https://ncbi.nlm.nih.gov/pubmed/25486251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0114782
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