Systematic dissection of the mechanisms underlying progesterone receptor downregulation in endometrial cancer

Progesterone, acting through its receptor, PR (progesterone receptor), is the natural inhibitor of uterine endometrial carcinogenesis by inducing differentiation. PR is downregulated in more advanced cases of endometrial cancer, thereby limiting the effectiveness of hormonal therapy. Our objective w...

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Vydáno v:Oncotarget
Hlavní autoři: Yang, Shujie, Jia, Yichen, Liu, Xiaoyue, Winters, Christopher, Wang, Xinjun, Zhang, Yuping, Devor, Eric J., Hovey, Adriann M., Reyes, Henry D., Xiao, Xue, Xu, Yang, Dai, Donghai, Meng, Xiangbing, Thiel, Kristina W., Domann, Frederick E., Leslie, Kimberly K.
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2014
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4259437/
https://ncbi.nlm.nih.gov/pubmed/25229191
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