Retroviral-mediated gene transfer corrects very-long-chain fatty acid metabolism in adrenoleukodystrophy fibroblasts.

Adrenoleukodystrophy (ALD), a lethal demyelinating disease of the brain, is caused by mutations of a gene encoding an ATP-binding transporter, called ALDP, localized in the peroxisomal membrane. It is associated with a defective oxidation of very-long-chain fatty acids, leading to their accumulation...

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Autors principals: Cartier, N, Lopez, J, Moullier, P, Rocchiccioli, F, Rolland, M O, Jorge, P, Mosser, J, Mandel, J L, Bougnères, P F, Danos, O
Format: Artigo
Idioma:Inglês
Publicat: 1995
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC42582/
https://ncbi.nlm.nih.gov/pubmed/7878038
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