A Gnotobiotic Mouse Model Demonstrates that Dietary Fiber Protects Against Colorectal Tumorigenesis in a Microbiota- and Butyrate–Dependent Manner

It is controversial whether dietary fiber protects against colorectal cancer because of conflicting results from human epidemiologic studies. However, these studies and mouse models of colorectal cancer have not controlled the composition of gut microbiota, which ferment fiber into short-chain fatty...

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Detalhes bibliográficos
Publicado no:Cancer Discov
Main Authors: Donohoe, Dallas R., Holley, Darcy, Collins, Leonard B., Montgomery, Stephanie A., Whitmore, Alan C., Hillhouse, Andrew, Curry, Kaitlin P., Renner, Sarah W., Greenwalt, Alicia, Ryan, Elizabeth P., Godfrey, Virginia, Heise, Mark T., Threadgill, Deborah S., Han, Anna, Swenberg, James A., Threadgill, David W., Bultman, Scott J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4258155/
https://ncbi.nlm.nih.gov/pubmed/25266735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-14-0501
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