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Closed-loop optimization of chromatography column sizing strategies in biopharmaceutical manufacture

BACKGROUND: This paper considers a real-world optimization problem involving the identification of cost-effective equipment sizing strategies for the sequence of chromatography steps employed to purify biopharmaceuticals. Tackling this problem requires solving a combinatorial optimization problem su...

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Detalhes bibliográficos
Publicado no:J Chem Technol Biotechnol
Main Authors: Allmendinger, Richard, Simaria, Ana S, Turner, Richard, Farid, Suzanne S
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Ltd 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4258073/
https://ncbi.nlm.nih.gov/pubmed/25506115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jctb.4267
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