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Closed-loop optimization of chromatography column sizing strategies in biopharmaceutical manufacture
BACKGROUND: This paper considers a real-world optimization problem involving the identification of cost-effective equipment sizing strategies for the sequence of chromatography steps employed to purify biopharmaceuticals. Tackling this problem requires solving a combinatorial optimization problem su...
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Publicado no: | J Chem Technol Biotechnol |
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Main Authors: | , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
John Wiley & Sons, Ltd
2014
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4258073/ https://ncbi.nlm.nih.gov/pubmed/25506115 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jctb.4267 |
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