The Discovery of Potent, Selective, and Reversible Inhibitors of the House Dust Mite Peptidase Allergen Der p 1: An Innovative Approach to the Treatment of Allergic Asthma

[Image: see text] Blocking the bioactivity of allergens is conceptually attractive as a small-molecule therapy for allergic diseases but has not been attempted previously. Group 1 allergens of house dust mites (HDM) are meaningful targets in this quest because they are globally prevalent and clinica...

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Опубликовано в: :J Med Chem
Главные авторы: Newton, Gary K., Perrior, Trevor R., Jenkins, Kerry, Major, Meriel R., Key, Rebekah E., Stewart, Mark R., Firth-Clark, Stuart, Lloyd, Steven M., Zhang, Jihui, Francis-Newton, Nicola J., Richardson, Jonathan P., Chen, Jie, Lai, Pei, Garrod, David R., Robinson, Clive
Формат: Artigo
Язык:Inglês
Опубликовано: American Chemical Society 2014
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4257840/
https://ncbi.nlm.nih.gov/pubmed/25365789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm501102h
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