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Evidence for a group II intron-like catalytic triplex in the spliceosome
To catalyze pre-mRNA splicing, U6 snRNA positions two metals that interact directly with the scissile phosphates. The U6 metal ligands correspond stereospecifically to metal ligands within the catalytic domain V of a group II self-splicing intron. In domain V, the ligands are organized by base-tripl...
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| Pubblicato in: | Nat Struct Mol Biol |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2014
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4257784/ https://ncbi.nlm.nih.gov/pubmed/24747940 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2815 |
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