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Injectable long-acting systems for Radix Ophiopogonis polysaccharide based on mono-PEGylation and in situ formation of a PLGA depot

BACKGROUND: Radix Ophiopogonis polysaccharide (ROP), a highly hydrophilic macromolecule, has a unique anti-ischemic action in the myocardium. One of the main problems with its use is its relatively short half-life in vivo. To solve this problem, injectable long-acting drug delivery systems, which co...

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Bibliografske podrobnosti
izdano v:Int J Nanomedicine
Main Authors: Shi, XiaoLi, Lin, Xiao, Zheng, XiangWei, Feng, Yi, Shen, Lan
Format: Artigo
Jezik:Inglês
Izdano: Dove Medical Press 2014
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4257019/
https://ncbi.nlm.nih.gov/pubmed/25489243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S71819
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