AIRE acetylation and deacetylation: effect on protein stability and transactivation activity

BACKGROUND: The AIRE protein plays a remarkable role as a regulator of central tolerance by controlling the promiscuous expression of tissue-specific antigens in thymic medullary epithelial cells. Defects in AIRE gene cause the autoimmune polyendocrinopathy- candidiasis-ectodermal dystrophy, a rare...

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Publicat a:J Biomed Sci
Autors principals: Incani, Federica, Serra, Maria Luisa, Meloni, Alessandra, Cossu, Carla, Saba, Luisella, Cabras, Tiziana, Messana, Irene, Rosatelli, Maria Cristina
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2014
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4256887/
https://ncbi.nlm.nih.gov/pubmed/25158603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12929-014-0085-z
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