Exposure−response modelling for empagliflozin, a sodium glucose cotransporter 2 (SGLT2) inhibitor, in patients with type 2 diabetes

AIMS: To provide model-based clinical development decision support including dose selection guidance for empagliflozin, an orally administered sodium glucose cotransporter 2 inhibitor, through developed exposure−response (E−R) models for efficacy and tolerability in patients with type 2 diabetes mel...

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Bibliographic Details
Published in:Br J Clin Pharmacol
Main Authors: Riggs, Matthew M, Seman, Leo J, Staab, Alexander, MacGregor, Thomas R, Gillespie, William, Gastonguay, Marc R, Woerle, Hans J, Macha, Sreeraj
Format: Artigo
Language:Inglês
Published: BlackWell Publishing Ltd 2014
Subjects:
Pharmacokinetic Dynamic Relationships
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4256629/
https://ncbi.nlm.nih.gov/pubmed/24964723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12453
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