Structural Maintenance of Chromosomes Flexible Hinge Domain Containing 1 (SMCHD1) Promotes Non-homologous End Joining and Inhibits Homologous Recombination Repair upon DNA Damage

Structural maintenance of chromosomes flexible hinge domain containing 1 (SMCHD1) has been shown to be involved in gene silencing and DNA damage. However, the exact mechanisms of how SMCHD1 participates in DNA damage remains largely unknown. Here we present evidence that SMCHD1 recruitment to DNA da...

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Vydáno v:J Biol Chem
Hlavní autoři: Tang, Mengfan, Li, Yujing, Zhang, Xiya, Deng, Tingting, Zhou, Zhifen, Ma, Wenbin, Songyang, Zhou
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2014
Témata:
DNA and Chromosomes
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4256338/
https://ncbi.nlm.nih.gov/pubmed/25294876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.601179
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