IGF-1 Promotes Brn-4 Expression and Neuronal Differentiation of Neural Stem Cells via the PI3K/Akt Pathway

Our previous studies indicated that transcription factor Brn-4 is upregulated in the surgically denervated hippocampus in vivo, promoting neuronal differentiation of hippocampal neural stem cells (NSCs) in vitro. The molecules mediating Brn-4 upregulation in the denervated hippocampus remain unknown...

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Pubblicato in:PLoS One
Autori principali: Zhang, Xinhua, Zhang, Lei, Cheng, Xiang, Guo, Yuxiu, Sun, Xiaohui, Chen, Geng, Li, Haoming, Li, Pengcheng, Lu, Xiaohui, Tian, Meiling, Qin, Jianbing, Zhou, Hui, Jin, Guohua
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2014
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4256305/
https://ncbi.nlm.nih.gov/pubmed/25474202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0113801
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