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Exploring O(2) Diffusion in A-Type Cytochrome c Oxidases: Molecular Dynamics Simulations Uncover Two Alternative Channels towards the Binuclear Site
Cytochrome c oxidases (Ccoxs) are the terminal enzymes of the respiratory chain in mitochondria and most bacteria. These enzymes couple dioxygen (O(2)) reduction to the generation of a transmembrane electrochemical proton gradient. Despite decades of research and the availability of a large amount o...
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| Pubblicato in: | PLoS Comput Biol |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Public Library of Science
2014
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4256069/ https://ncbi.nlm.nih.gov/pubmed/25474152 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1004010 |
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