PLD3 is accumulated on neuritic plaques in Alzheimer’s disease brains

INTRODUCTION: Recently, a whole-exome sequencing (WES) study showed that a rare variant rs145999145 composed of p.Val232Met located in exon 7 of the phospholipase D3 (PLD3) gene confers a doubled risk for late-onset Alzheimer’s disease (AD). Knockdown of PLD3 elevates the levels of extracellular amy...

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Detalhes bibliográficos
Publicado no:Alzheimers Res Ther
Main Authors: Satoh, Jun-ichi, Kino, Yoshihiro, Yamamoto, Yoji, Kawana, Natsuki, Ishida, Tsuyoshi, Saito, Yuko, Arima, Kunimasa
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4255636/
https://ncbi.nlm.nih.gov/pubmed/25478031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13195-014-0070-5
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