iPS Cell-Derived Dopamine Neurons Reveal Differences between Monozygotic Twins Discordant for Parkinson’s Disease

Parkinson’s disease (PD) has been attributed to a combination of genetic and non-genetic factors. We studied a set of monozygotic twins harboring the heterozygous glucocerebrosidase mutation (GBA N370S) but clinically discordant for PD. We applied induced pluripotent stem (iPS) cell technology for P...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Woodard, Chris M., Campos, Brian A., Kuo, Sheng-Han, Nirenberg, Melissa J., Nestor, Michael W., Zimmer, Matthew, Mosharov, Eugene, Sulzer, David, Zhou, Hongyan, Paull, Daniel, Clark, Lorraine, Schadt, Eric E., Sardi, Sergio Pablo, Rubin, Lee, Eggan, Kevin, Brock, Mathew, Lipnick, Scott, Rao, Mahendra, Chang, Stephen, Li, Aiqun, Noggle, Scott
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4255586/
https://ncbi.nlm.nih.gov/pubmed/25456120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.10.023
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