Cardiac dysfunction in β-carotene-15,15′-dioxygenase-deficient mice is associated with altered retinoid and lipid metabolism

Dietary carotenoids like β-carotene are converted within the body either to retinoid, via β-carotene-15,15′-dioxygenase (BCO1), or to β-apo-carotenoids, via β-carotene-9′,10′-oxygenase 2. Some β-apo-carotenoids are potent antagonists of retinoic acid receptor (RAR)-mediated transcriptional regulatio...

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Bibliographic Details
Published in:Am J Physiol Heart Circ Physiol
Main Authors: Lee, Seung-Ah, Jiang, Hongfeng, Trent, Chad M., Yuen, Jason J., Narayanasamy, Sureshbabu, Curley, Robert W., Harrison, Earl H., Goldberg, Ira J., Maurer, Mathew S., Blaner, William S.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2014
Subjects:
Integrative Cardiovascular Physiology and Pathophysiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4255008/
https://ncbi.nlm.nih.gov/pubmed/25260612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00548.2014
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