Polymorphism in the 5' flanking region of the human insulin gene. Relationships with noninsulin-dependent diabetes mellitus, glucose and insulin concentrations, and diabetes treatment in the Pima Indians.

Variations in DNA sequences flanking the insulin gene were studied in relation to noninsulin-dependent diabetes mellitus (NIDDM) in 87 unrelated Pima Indians at least 35 yr of age. DNA was isolated from nuclei of peripheral blood leukocytes and digested with restriction endonucleases. Less variation...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Knowler, W C, Pettitt, D J, Vasquez, B, Rotwein, P S, Andreone, T L, Permutt, M A
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 1984
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC425404/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6392341/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI111638
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